Weight
Yep, you betcha! We use full-grain leather, and it is THICK. We choose to use this thicker leather for its increased durability, and the awesome way it breaks in overtime. Wheeled luggage carts definitely come in handy if you're planning on trekking through the airport with an entire herd of our gear.
Thin leather just doesn't last or age well. If you want something that ages well and lasts, you'll need to invest in something with heavier leather. Some have complained that the briefcase is too heavy for them. Normally smaller framed women tell me this. The suitcases aren't too heavy for anyone as long as you have a wheeled carrier like I do. Even if I had luggage with wheels, I would use it every time I traveled for carrying my carry-ons from the baggage check to the airplane. There is a number of them out there to choose from. I'm currently using one from Samsonite.